Pharmacodynamic Effects of a New Antihypertensive Drug, Catapres (ST-155)

Pharmacodynamic effects of a new antihypertensive drug, Catapres (ST-155).

Catapres is a new imidazoline compound with potent antihypertensive properties. Significant reduction in blood pressure occurs between 1 and 4 hours after oral administration, with the peak effect occurring at 2 to 4 hours and the antihypertensive effect extending for 6 to 10 hours. Blood pressure is reduced in both the supine and erect positions, although the orthostatic response is the more p...

مکانیسم تاثیر داروهای جدید موثر در درمان افزایش فشار خون شریانی ( خواص فارماکولوژیک   ST 155 = Clonidine = Catapres )  

Pharmacokinetic-pharmacodynamic Modeling of Antihypertensive Drugse

Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identificat...

Biomarkers in Transplantation Medicine: Prediction of Pharmacodynamic Drug Effects

Conventional therapeutic drug monitoring based on measuring of blood concentrations (pharmacokinetic) is important in the clinical management of immunosuppressive therapy in transplantation medicine. Since rejection or infection occurs at irregular drug concentrations, immunosuppressive drug therapy is often empiric and prophylactic in nature. In addition, blood immunosuppressant levels are onl...

Differential effects of antihypertensive drug therapy on arterial compliance.

Although vascular compliance, deltaV/deltaP, is abnormal in essential hypertension and can be improved by antihypertensive drug therapy, it is not clear whether drug-induced changes in compliance are attributable solely to lower achieved blood pressure (BP), and thus equally likely with different drugs possessing similar antihypertensive efficacy. Therefore, we used computerized arterial pulse ...